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This article reviews the general and discriminating markers of microglia as described in recent literature. Resting microglia with ramified morphology, and reactive microglia with an amoeboid shape in response to a pathological environment. The distinction between resident microglia and infiltrating myeloid cells is often made using specific markers such as tmem119 and p2ry12, which help identify the microglial cells within the cns.
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Click here to see a full list of microglia cell markers. It is well documented that two functional states are associated with microglia The information provided here creates a comprehensive and practical guide through the current knowledge and will facilitate the choosing of proper, more specific markers for detailed studies on microglia and neuroinflammatory mechanisms in various physiological as well as pathological conditions.
The use of microglia markers can also help identify changes in microglial function that occur during injury or disease
